PIQRAY® (alpelisib) | PIK3CA-mutated advanced breast cancer

For Healthcare Professionals Outside the US
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PIQRAY Highlights podcast
Talking PIQRAY Podcast Series
Check out the first season of Talking PIQRAY, a podcast series dedicated to exploring data, patient management considerations, and more.
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PIQRAY mechanism of action
PIQRAY Videos
Learn more about PIQRAY from multiple experts in the treatment of HR+/HER2- aBC. Topics include clinical trial data, mechanism of action, and patient management.
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Indication from Summary of Product Characteristics

PIQRAY is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)‐positive, human epidermal growth factor receptor 2 (HER2)‐negative, locally advanced or metastatic breast cancer with a PIK3CA mutation after disease progression following endocrine therapy as monotherapy.
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Patients with a
PIK3CA mutation
face a poor prognosis1
Learn more about the PIK3CA mutation
~40% of patients with HR+/HER2- aBC have a PIK3CA mutation
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PIQRAY addresses
PIK3CA mutations by
targeting PI3Kα,
a key upstream
component of the
PI3K pathway3,4
Find out how
PIQRAY works
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PIQRAY mechanism of action PIQRAY mechanism of action
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Nearly doubled mPFS
in patients with a
PIK3CA mutation4,5
See the efficacy
of PIQRAY
PIQRAY median progression-free survival chart
Downloadable management checklists icon
Downloadable management
checklists
Stay up to date with key information
for treatment management
Start your checklist
See the patient management tool, treatment management checklists, and more PIQRAY patient resources.
PIQRAY Patient Management Tool icon
Keeping TRAQ with PIQRAY:
Patient Management tool
Click through relevant
considerations for selected adverse reactions
Explore the tool
Progression free chart image Progression free chart image
References: 1. Mosele F,
Stefanovska B,
Lusque A,
et al.
Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer. Ann Oncol. 2020;31(3):377-386. 2. The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70. 3. Chalhoub C, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 2009;4:127-150. 4. Piqray® (alpelisib) EU Summary of Product Characteristics. Novartis; May 2021. 5. André F, Ciruelos E, Rubovszky G, et al. Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer. N Engl J Med. 2019;380(20):1929-1940.